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Plavix (Clopidogrel) is used to prevent strokes and heart attacks.

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Drug Name

Plavix (Clopidogrel)

Drug Uses

Clopidogrel is used to prevent strokes and heart attacks in persons who are at high risk. In one large study, clopidogrel was more effective than aspirin in reducing heart attacks. The frequency of side effects of clopidogrel was similar to aspirin; however, stomach and intestinal bleeding probably occurs less often with clopidogrel than with aspirin.

How Taken

Take clopidogrel exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Clopidogrel can be taken with or without food.

Drug Class and Mechanism

Clopidogrel is an anti-platelet drug, that is, a drug that inhibits the ability of platelets to clump together as part of a blood clot. It is similar to ticlopidine (Ticlid) in chemical structure and in the way it works. Unlike ticlopidine, clopidogrel does not cause serious reductions of white cells in the blood and, therefore, routine blood testing to determine if the white blood cell count is low is not necessary during treatment. The risk of heart attacks and strokes (which usually are caused by blood clots) is increased in patients with a recent history of stroke or heart attack and patients with peripheral vascular disease. (Peripheral vascular disease is the same as atherosclerotic arterial disease or "hardening" of the arteries in which the arteries become narrowed. It frequently occurs in the legs and often causes claudication or pain in the legs upon walking). Clopidogrel is used to reduce the risk of heart attacks and strokes in these patients. Clopidogrel was approved by the FDA in 1997.

Missed Dose

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

Storage

Tablets should be stored at room temperature, 15-30 degrees C (59-86 degrees F), away from moisture and heat.

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